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Cytogenetic Testing
How Many of Your Patients are High Risk?*1,2
Cytogenetic testing is an important step in the diagnosis, prognosis, and risk stratification of patients with acute myeloid leukaemia (AML).3,4 It also plays a key role in predicting how well a patient will respond to treatment, helping you shape their therapeutic options3,4
The evolving AML treatment landscape
With a growing number of therapeutic options, making optimal treatment decisions for the individual has become increasingly complex.3
That’s where cytogenetic testing can help4
Learn more with Prof. Nigel Russell
Waiting for cytogenetic test results before assigning stable patients to the most suitable treatment is a reasonable approach5-7
Waiting to receive cytogenetic test results before assigning an intensive therapeutic regimen to clinically stable patients is supported by the outcomes from a study of the relationship between time from diagnosis to treatment (TDT) and prognosis on a large set of real-world data from the AML registry of the Study Alliance Leukemia6
Overall survival (OS) according to TDT in all patients (N=2,263)6
Multivariable analyses showed:
TDT did not affect the likelihood of complete remission (CR)/CR with incomplete platelet or neutrophil recovery (CRi), early mortality, or long-term OS6
In the study:6
– 96.6% of patients received daunorubicin cytarabine (DA) 3+7, 2.7% were treated with high-dose cytosine arabinoside and mitoxantrone, and 0.7% with high-dose cytarabine/intermediate-dose cytarabine
– 75% had de novo AML, 15.1% had secondary AML (s-AML), and 9.9% had therapy-related AML (t-AML)
Guidelines recommend selecting treatment according to the patient’s disease and cytogenetic profile3,5,8
Adapted From the Greater Manchester Cancer Haemato-Oncology Pathway: Guidelines for the Management of Acute Myeloid Leukaemia8
This schematic relates to the selection of intensive chemotherapy
Vyxeos Liposomal is indicated for the treatment of adults with newly-diagnosed t-AML or AML-MRC.10 See more here.
Bristol case study:
routine use of cytogenetics
A close professional relationship between the laboratory and clinical team at University Hospitals Bristol NHS Foundation Trust enables the rapid turn around of molecular and cytogenetic test results. It is standard practice at the Trust to wait for and use those results to direct therapy from the beginning, tailoring treatment according to prognostic need
Disclaimer: This treatment approach is subject to the physician’s discretion and may depend on the patient’s individual condition and circumstances.
Clinically stable AML patients can wait for cytogenetic test results
Before they are prescribed the optimal treatment for their cancer3-6
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